Investigating the impact of a variable RBE on proton dose fractionation across an actively scanned spread-out Bragg peak.
نویسندگان
چکیده
منابع مشابه
Investigating the Implications of a Variable RBE on Proton Dose Fractionation Across a Clinical Pencil Beam Scanned Spread-Out Bragg Peak.
PURPOSE To investigate the clinical implications of a variable relative biological effectiveness (RBE) on proton dose fractionation. Using acute exposures, the current clinical adoption of a generic, constant cell killing RBE has been shown to underestimate the effect of the sharp increase in linear energy transfer (LET) in the distal regions of the spread-out Bragg peak (SOBP). However, experi...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2016
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(16)30179-7